Жолдасбекова, А.Е. and Бияшев, К.Б. and Бияшев, Б.К. and Киркимбаева, Ж.С. and Волдовска, А. (2018) Control of stability of the residual virulence of the attenuated strain Salmonella Dublin 31. Известия Национальной академии наук Республики Казахстан, 3 (45). pp. 5-9. ISSN 2224-526Х
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Abstract
In recent years, live vaccines based on attenuated strains have been successfully used in agricultural animals and birds to prevent salmonellosis in our country and abroad. This article presents the results of monitoring the stability of the residual virulence of the attenuated strain Salmonella dublin 31. Our studies showed that the attenuated strain Salmonella dublin 31 retained the typical morphological, tinctorial, cultural, biochemical and antigenic properties that are characteristic of the corresponding serovar. The residual virulence of the vaccine strain Salmonella dublin 31 was tested in comparison with the virulent Salmonella dublin 315/52 culture in white mice (weighing 14-16 g), guinea pigs (weight 240-290) in several repetitions, taking into account their survival, dissemination of the process and timing elimination of attenuated vaccine strain culture. Studies have shown that all mice and guinea pigs infected with culture Salmonella dublin 31 survive 90-100% of cases during 20 days of observation, while control test animals infected with the virulent culture of S.dublin 315/52 at a dose of 104, 105, 106 CFU perished from 60% to 100% of cases.
| Item Type: | Article |
|---|---|
| Subjects: | Veterinary |
| Depositing User: | Асель Еркинбекова Жолдасбекова |
| Date Deposited: | 05 Apr 2019 03:20 |
| Last Modified: | 05 Apr 2019 03:20 |
| URI: | http://repository.kaznau.kz/id/eprint/1008 |
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